应用于内窥镜的聚酰亚胺涂覆双包层光纤束

萧恩; 吴开杰; 谷朝臣; 关新平

doi:10.3788/OPE.20192701.0017

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应用于内窥镜的聚酰亚胺涂覆双包层光纤束

现代应用光学 | 更新时间：2020-08-13

- 应用于内窥镜的聚酰亚胺涂覆双包层光纤束
- Polyimide-coated fiber-optic bundle comprising double clad fibers for endoscopy
- 光学精密工程 2019年27卷第1期页码：17-25
- 作者机构：
  
  上海交通大学电子信息与电气工程学院自动化系系统控制与信息处理教育部重点实验室，上海 200240
- 作者简介：
  
  [ "Shawn Patrick Casey, PhD candidate/CSC scholarship student, Shanghai Jiao Tong University, School of Electronic Information and Electrical Engineering, Department of Automation, Key Laboratory of System Control and Information Processing, Ministry of Education of China. He is the former secretary and vice chair of the IEEE Photonics Society NJ Coast Section, having served as a non-voting member of the Board of Governors in that role. Research interests: Optics, image processing, and microscopy. E-mail:shawncasey@sjtu.edu.cn" ]
  [ "WU Kai-jie, Associate Professor, Shanghai Jiao Tong University, School of Electronic Information and Electrical Engineering, Department of Automation, Key Laboratory of System Control and Information Processing, Ministry of Education of China. Research interest: Microscopy, digital pathology, medical image processing, and pattern recognition. E-mail: kaijiewu@sjtu.edu.cn" ]
- 基金信息：
  
  国家重点科学仪器设备开发专项(2013YQ03065101);国家自然科学基金资助项目(61503243)
- DOI：10.3788/OPE.20192701.0017
  中图分类号： TN253
- 收稿日期：2018-08-08，
  
  录用日期：2018-9-14，
  
  纸质出版日期：2019-01-15
- 稿件说明：
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萧恩, 吴开杰, 谷朝臣, 等. 应用于内窥镜的聚酰亚胺涂覆双包层光纤束[J]. 光学精密工程, 2019,27(1):17-25.

CASEY Patrick Shawn, Kai-jie WU, Chao-chen GU, et al. Polyimide-coated fiber-optic bundle comprising double clad fibers for endoscopy[J]. Optics and precision engineering, 2019, 27(1): 17-25.
萧恩, 吴开杰, 谷朝臣, 等. 应用于内窥镜的聚酰亚胺涂覆双包层光纤束[J]. 光学精密工程, 2019,27(1):17-25. DOI： 10.3788/OPE.20192701.0017.

CASEY Patrick Shawn, Kai-jie WU, Chao-chen GU, et al. Polyimide-coated fiber-optic bundle comprising double clad fibers for endoscopy[J]. Optics and precision engineering, 2019, 27(1): 17-25. DOI： 10.3788/OPE.20192701.0017.

摘要

本文研究了一种适用于临床前研究的小型化(< 0.4 mm)、低成本纤维束内窥镜装置。该装置包含有一个渐变折射率(GRIN)透镜，它安装在光纤图像引导器的近端。提出了一种简化、低成本的装置连接方案，并讨论了可应用的连接方案。装置中使用的纤维束表面包覆有聚酰亚胺，其在长期和短期植入时都具有生物相容性。最终制备的装置能够承受化学清洗、消毒和高压灭菌，满足普通实验室和临床程序的需求，并且对整体性能有较小的影响。为了验证纤维束的成像质量，本文使用标准测试靶标和荧光微球进行评估。结果表明，光纤与自发荧光之间的串扰对成像质量的影响很小，该纤维束无需复杂光路和激光扫描即可实现荧光样品分子级的分辨率。

Abstract

A miniaturized (< 0.4 mm)

low-cost fiber bundle based endoscope suitable for pre-clinical research was presented. The device incorporates a Gradient-Index (GRIN) lens bonded to the proximal end of a fiber-optic image guide. Further

a simplified

low-cost connectorization method was proposed and connectorization for alternative applications was discussed. The fiber bundle was coated with polyimide which was bio-compatible for both long- and short-term implantation. In keeping with common laboratory and clinical procedures

the finished assembly allows for chemical cleaning

disinfection and autoclave sterilization with negligible impact on the overall performance of the device. The performance was evaluated by using standard test targets for white light as well as fluorescent microspheres to verify image quality. The results show that the effects of crosstalk between fibers and autofluroescence have a minimal impact on image quality. The fiber bundle assembly is able to resolve fluorescent samples at cellular resolution without the need for a complex optical path or laser scanning mechanism.

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references

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