透射共轴式光声消化内窥成像系统

王柏权; 陈宁波; 张建辉; 龚小竞

doi:10.3788/OPE.20202801.0069

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透射共轴式光声消化内窥成像系统

现代应用光学 | 更新时间：2020-08-13

- 透射共轴式光声消化内窥成像系统
- Transmissive coaxial photoacoustic endoscopic imaging system for digestive tract
- 光学精密工程 2020年28卷第1期页码：69-79
- 作者机构：
  
  1.中国科学院深圳先进技术研究院生物医学光学与分子影像研究室，广东深圳 518055；
  2.广州大学机械与电气工程学院，广东广州 510006
- 作者简介：
  
  [ "王柏权(1994-)，男，广东湛江人，博士研究生，主要从事光声内窥成像系统、光声光谱成像系统设计等方面的研究。E-mail：1205173349@qq.com" ]
  [ "张建辉(1963-)，男，吉林长春人，博士，教授，博士生导师，主要从事光声成像、机械设计及理论等方面的研究。E-mail：zhangjh@nuaa.edu.cn" ]
  [ "龚小竞(1978-)，男，安徽合肥人，博士，副研究员，主要从事生物医学光声成像、光声内窥成像及其临床应用、光声光谱成像等方面的研究。E-mail:xj.gong@siat.ac.cn" ]
- 基金信息：
  
  深圳市科技计划项目(JCYJ20160608214524052);中国科学院-威高研究发展计划攻关项目(中科院威高计划[2017]011号);广州大学科研能力提升计划项目(2018A001)
- DOI：10.3788/OPE.20202801.0069
  中图分类号： Q334; Q631
- 收稿日期：2019-07-25，
  
  录用日期：2019-8-19，
  
  纸质出版日期：2020-01-15
- 稿件说明：
移动端阅览
王柏权, 陈宁波, 张建辉, 等. 透射共轴式光声消化内窥成像系统[J]. 光学精密工程, 2020,28(1):69-79.

Bo-quan WANG, Ning-bo CHEN, Jian-hui ZHANG, et al. Transmissive coaxial photoacoustic endoscopic imaging system for digestive tract[J]. Optics and precision engineering, 2020, 28(1): 69-79.
王柏权, 陈宁波, 张建辉, 等. 透射共轴式光声消化内窥成像系统[J]. 光学精密工程, 2020,28(1):69-79. DOI： 10.3788/OPE.20202801.0069.

Bo-quan WANG, Ning-bo CHEN, Jian-hui ZHANG, et al. Transmissive coaxial photoacoustic endoscopic imaging system for digestive tract[J]. Optics and precision engineering, 2020, 28(1): 69-79. DOI： 10.3788/OPE.20202801.0069.

摘要

光声成像作为一种既能提供光学高对比度又能实现声学大成像深度的新兴医学影像技术，可通过对肿瘤滋养血管的三维成像，为癌症的早期诊断提供一种全新的高灵敏检测方法。本文针对消化道肿瘤的临床成像需求，提出了一种内部光激发、外部声探测的透射共轴式光声消化道内窥成像系统，并通过仿体与离体生物组织的成像实验，与现有的反射非共轴式光声内窥成像系统的成像性能进行了对比。实验结果表明，在仿体样品中，透射共轴式光声内窥成像系统的信噪比相对反射非共轴式系统最高提高了43.3 dB，成像深度增大了28.4%；而离体生物组织中，在10.7 mm深处，其信噪比也提高了9.7 dB。实验验证了本设计有效提高了光声信号的探测灵敏度，使该系统相较现有反射式系统具备更优的成像信噪比和成像深度，为光声消化道内窥技术推向临床提供了一种具有重要应用潜力的实施方法。

Abstract

Photoacoustic imaging is an emerging medical imaging technique combining the high contrast of optical imaging and the superior penetration depth of ultrasound imaging. It can provide detailed three-dimensional images of the feeding vessels of tumors

which is essential for the early diagnosis of cancer. In this study

we developed a transmissive coaxial photoacoustic digestive tract endoscopic imaging system using internal optical illumination and external ultrasonic detection. The phantom imaging results indicated that the transmissive system has a much better performance than the reflective non-coaxial system with a 43.3 dB higher Signal-to-Noise Ratio (SNR) and 28.4% better imaging depth. Ex vivo imaging results indicated that the transmissive system has a 9.7 dB higher SNR at a depth of 10.7 mm compared with the reflective system. The transmissive coaxial photoacoustic endoscopic imaging system

which exhibited a higher SNR and better imaging depth than the reflective system

shows that this design improves the detection sensitivity effectively. The significant improvements suggest that the developed photoacoustic endoscopy has great potential for translation into a broad range of clinical applications in gastroenterology.

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references

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